IN2015DN01767A - - Google Patents

Info

Publication number
IN2015DN01767A
IN2015DN01767A IN1767DEN2015A IN2015DN01767A IN 2015DN01767 A IN2015DN01767 A IN 2015DN01767A IN 1767DEN2015 A IN1767DEN2015 A IN 1767DEN2015A IN 2015DN01767 A IN2015DN01767 A IN 2015DN01767A
Authority
IN
India
Prior art keywords
probnp
mortality
transplantation
subjects
prediction
Prior art date
Application number
Other languages
English (en)
Inventor
James V Snider
Robert W Gerwien
Sven Jacobson
Original Assignee
Critical Care Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Critical Care Diagnostics Inc filed Critical Critical Care Diagnostics Inc
Publication of IN2015DN01767A publication Critical patent/IN2015DN01767A/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment

Landscapes

  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Primary Health Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
IN1767DEN2015 2012-08-21 2013-08-21 IN2015DN01767A (en])

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261691706P 2012-08-21 2012-08-21
PCT/US2013/056020 WO2014031764A1 (en) 2012-08-21 2013-08-21 Multimarker risk stratification

Publications (1)

Publication Number Publication Date
IN2015DN01767A true IN2015DN01767A (en]) 2015-05-29

Family

ID=50148799

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1767DEN2015 IN2015DN01767A (en]) 2012-08-21 2013-08-21

Country Status (12)

Country Link
US (4) US20140058743A1 (en])
EP (1) EP2888687B1 (en])
JP (3) JP6450679B2 (en])
CN (2) CN111834009A (en])
AU (3) AU2013305829A1 (en])
CA (1) CA2882303A1 (en])
HK (2) HK1208092A1 (en])
IN (1) IN2015DN01767A (en])
MX (2) MX375520B (en])
RU (1) RU2015110054A (en])
SG (2) SG10201608854TA (en])
WO (1) WO2014031764A1 (en])

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002218026A1 (en) 2000-11-09 2002-05-21 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
ATE534747T1 (de) 2002-05-09 2011-12-15 Brigham & Womens Hospital 1l1rl-1 als marker für kardiovaskuläre erkrankungen
ES2378314T3 (es) 2006-04-24 2012-04-11 Critical Care Diagnostics, Inc. Predicción de la mortalidad y detección de enfermedades graves.
SI2482078T1 (sl) 2006-05-01 2016-05-31 Critical Care Diagnostics, Inc. Diagnosticiranje kardiovaskularne bolezni
SI2269063T1 (sl) 2008-04-18 2014-01-31 Critical Care Diagnostics, Inc. Napoved tveganja večjih neugodnih pojavov na srcu
US8420785B2 (en) 2010-04-09 2013-04-16 Critical Care Diagnostics, Inc. Soluble human ST-2 antibodies and assays
ES2750126T3 (es) 2011-03-17 2020-03-25 Critical Care Diagnostics Inc Procedimientos de predicción del riesgo de un resultado clínico adverso
US8748110B2 (en) 2011-07-18 2014-06-10 Critical Care Diagnostics, Inc. Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
MX357740B (es) 2012-05-18 2018-07-23 Critical Care Diagnostics Inc Métodos para determinar el pronóstico del tratamiento de un sujeto con un desfibrilador cardíaco implantado, un dispositivo de tratamiento de resincronización cardíaca o un dispositivo combinado de desfibrilador cardíaco implantado y de resincronización cardíaca.
MX382403B (es) 2012-08-16 2025-03-13 Critical Care Diagnostics Inc Métodos para predecir el riesgo de desarrollar hipertensión.
IN2015DN01767A (en]) 2012-08-21 2015-05-29 Critical Care Diagnostics Inc
AU2015204675A1 (en) * 2014-01-10 2016-07-28 Critical Care Diagnostics, Inc. Methods and systems for determining risk of heart failure
US10079073B2 (en) 2014-12-11 2018-09-18 Critical Care Diagnostics, Inc. Test apparatus and methods for ST2 cardiac biomarker
US10324089B2 (en) 2014-12-11 2019-06-18 Critical Care Diagnostics, Inc. Test apparatus and methods for ST2 cardiac biomarker
CA2996903C (en) 2015-08-28 2024-01-02 Mcmaster University Method of determining risk of an adverse cardiac event
US20170220749A1 (en) * 2016-02-01 2017-08-03 MD Aware LLC Systems and methods for identifying and using medical calculators
CN109863404A (zh) * 2016-04-18 2019-06-07 豪夫迈·罗氏有限公司 用于鉴定一般群体中lvh的进展者的可溶性st2
US12014832B2 (en) * 2017-06-02 2024-06-18 University Of Florida Research Foundation, Incorporated Method and apparatus for prediction of complications after surgery
RU2677611C1 (ru) * 2018-04-16 2019-01-17 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ прогнозирования неблагоприятных сердечно-сосудистых событий в течение 12 месяцев у больных хронической сердечной недостаточностью с рецидивом стенокардии после реваскуляризации миокарда
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US12264366B2 (en) 2019-05-17 2025-04-01 Regeneron Pharmaceuticals, Inc. Genome-based methods for reducing cardiovascular risk
JP7420145B2 (ja) * 2019-11-01 2024-01-23 日本電気株式会社 リスク予測装置、リスク予測方法、及びコンピュータプログラム
CN118760892B (zh) * 2024-09-05 2024-11-19 温州市中心医院 铁死亡评分确定方法、系统及设备

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
US5206140A (en) 1988-06-24 1993-04-27 Research Corporation Technologies, Inc. Assay for soluble crosslinked fibrin polymers
JPH0731479Y2 (ja) 1989-06-02 1995-07-19 内橋エステック株式会社 温度ヒューズ
US5217899A (en) 1990-08-24 1993-06-08 The General Hospital Corporation Cell stretching apparatus
JP2665850B2 (ja) 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
JP2732005B2 (ja) 1992-12-14 1998-03-25 眞一 富永 ヒトｓｔ２をコードするｄｎａ、該ｄｎａの発現産物、該ｄｎａを発現させることによる発現産物の製造方法
US6066322A (en) 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
AU7235296A (en) 1996-08-23 1998-03-06 Human Genome Sciences, Inc. T1 receptor-like ligand ii
EP0981619A1 (en) 1997-02-28 2000-03-01 Human Genome Sciences, Inc. T1/st2-receptor ligand iii
EP2305236A1 (en) 1997-04-02 2011-04-06 The Brigham And Women's Hospital, Inc. Means of Ascertaining an Individual's Risk Profile for Atherosclerotic Disease
US6210976B1 (en) 1997-06-10 2001-04-03 Medlyte Diagnostics, Inc. Methods for early detection of heart disease
DE69833118T2 (de) 1997-09-11 2006-08-31 Shionogi & Co., Ltd. Immunoassay zum bestimmen von bnp
US6309888B1 (en) 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
GB9827348D0 (en) 1998-12-12 1999-02-03 Univ Leicester Natriuretic peptide
AU2055300A (en) 1998-12-18 2000-07-03 Scios Inc. Methods for detection and use of differentially expressed genes in disease states
AU5309600A (en) 1999-06-02 2000-12-18 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
FR2795823B1 (fr) 1999-07-01 2001-11-23 Inst Nat Sante Rech Med Methodes et kits pour le diagnostic ou le suivi d'une pathologie synoviale ou osteoarticulaire comprenant l'utilisation d'un marqueur specifique de la degradation du tissu synovial
US6323334B1 (en) 1999-09-24 2001-11-27 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding a 103 gene product and uses therefor
AU2001218871A1 (en) 2000-03-21 2001-10-03 Takao Arai Monoclonal antibody and method and kit for the immunoassay of soluble human st2 with the use of the same
FR2807170B1 (fr) 2000-03-30 2002-06-28 Sipal Charniere elastique a frottement reduit
AU8513901A (en) 2000-08-22 2002-03-04 Brigham And Women's Hospital Diagnosis and treatment of cardiovascular conditions
AU2002218026A1 (en) 2000-11-09 2002-05-21 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
US6537221B2 (en) 2000-12-07 2003-03-25 Koninklijke Philips Electronics, N.V. Strain rate analysis in ultrasonic diagnostic images
FI20010019A7 (fi) 2001-01-05 2002-07-06 Biohit Oyj Menetelmä atrofisen gastriitin diagnostisoimiseksi
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040253637A1 (en) 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
EP2261669A1 (en) 2001-05-04 2010-12-15 Alere San Diego, Inc. Diagnostic markers of acute coronary syndromes and methods of use thereof
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
WO2003022987A2 (en) 2001-07-26 2003-03-20 Eos Biotechnology, Inc. Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection
US6810284B1 (en) 2001-11-21 2004-10-26 Pacesetter, Inc. Implantable cardiac stimulation system and method for monitoring diastolic function
ATE534747T1 (de) 2002-05-09 2011-12-15 Brigham & Womens Hospital 1l1rl-1 als marker für kardiovaskuläre erkrankungen
US8263325B2 (en) 2002-11-15 2012-09-11 Ottawa Heart Institute Research Corporation Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis
US20070042978A1 (en) 2002-12-19 2007-02-22 Jean-Philippe Girard Nf-hev compositions and methods of use
US20040133079A1 (en) 2003-01-02 2004-07-08 Mazar Scott Thomas System and method for predicting patient health within a patient management system
US20040220155A1 (en) 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
US20050123451A1 (en) 2003-10-31 2005-06-09 Hiroshi Nomura System and apparatus for body fluid analysis using surface-textured optical materials
JP5649263B2 (ja) 2003-11-26 2015-01-07 セレラ コーポレーション 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途
EP2306192B1 (en) 2003-12-05 2015-10-14 The Cleveland Clinic Foundation Risk Markers For Cardiovascular Disease
US20050196817A1 (en) 2004-01-20 2005-09-08 Molecular Staging Inc. Biomarkers for sepsis
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
JP2005291899A (ja) 2004-03-31 2005-10-20 Akira Matsumori 心疾患の検査法
ES2316044T3 (es) 2005-01-24 2009-04-01 F. Hoffmann-La Roche Ag El uso de hormonas cardiacas para evaluar un riesgo cardiovascular con respecto a la administracion de farmacos antiinflamatorios.
EP1731910A1 (en) 2005-06-07 2006-12-13 F. Hoffmann-La Roche Ag Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases
US20070021977A1 (en) 2005-07-19 2007-01-25 Witt Biomedical Corporation Automated system for capturing and archiving information to verify medical necessity of performing medical procedure
JP4820192B2 (ja) 2006-03-17 2011-11-24 一般財団法人化学及血清療法研究所 急性冠症候群でのａｄａｍｔｓ１３の測定と利用
ES2378314T3 (es) * 2006-04-24 2012-04-11 Critical Care Diagnostics, Inc. Predicción de la mortalidad y detección de enfermedades graves.
WO2007143295A2 (en) 2006-04-27 2007-12-13 Critical Care Diagnostics, Inc. Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease
SI2482078T1 (sl) * 2006-05-01 2016-05-31 Critical Care Diagnostics, Inc. Diagnosticiranje kardiovaskularne bolezni
ES2723957T3 (es) 2006-05-02 2019-09-04 Critical Care Diagnostics Inc Procedimiento de selección de un tratamiento basado en el diagnóstico diferencial entre enfermedad pulmonar y cardiovascular
US8147817B2 (en) 2006-05-04 2012-04-03 The Brigham And Women's Hospital, Inc. IL-33 in the treatment and diagnosis of diseases and disorders
RU2312591C1 (ru) 2006-06-14 2007-12-20 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" Способ прогнозирования развития риска внезапной смерти у больных с лево- и правожелудочковой экстрасистолией
CA2554659A1 (en) * 2006-07-25 2006-11-24 1128971 Alberta Ltd. Hanger flange for hanging a tubular body in a well
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
US20090111708A1 (en) * 2007-05-11 2009-04-30 Seddon Johanna M Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk
US20100267062A1 (en) * 2007-09-26 2010-10-21 Norbert Frey Osteopontin as Novel Prognostic Biomarker for Heart Failure
FR2923029B1 (fr) 2007-10-26 2009-11-20 Minima Lunettes de type sans entourage a branches filaires
WO2009075566A1 (en) * 2007-12-12 2009-06-18 Erasmus University Medical Center Rotterdam Biomarkers for cardiovascular disease
SI2269063T1 (sl) * 2008-04-18 2014-01-31 Critical Care Diagnostics, Inc. Napoved tveganja večjih neugodnih pojavov na srcu
US20100159474A1 (en) * 2008-11-11 2010-06-24 B.R.A.H.M.S. Aktiengesellschaft Prognosis and risk assessment in patients suffering from heart failure by determining the level of adm and bnp
US20120116817A1 (en) * 2009-07-01 2012-05-10 Chantal Boulanger Methods for Predicting Cardiovascular Mortality Risk
JP5728488B2 (ja) * 2009-11-13 2015-06-03 ビージー メディシン， インコーポレイテッド 心筋梗塞のリスクファクターおよび予測
US8258456B2 (en) * 2009-11-27 2012-09-04 Himax Imaging, Inc. Image sensor
US8420785B2 (en) 2010-04-09 2013-04-16 Critical Care Diagnostics, Inc. Soluble human ST-2 antibodies and assays
EP2635904A1 (en) * 2010-11-01 2013-09-11 B.R.A.H.M.S GmbH Prognosis and risk assessment of patients with non-specific complaints
RU2452394C1 (ru) 2010-11-09 2012-06-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Ульяновский государственный университет Способ прогнозирования риска смерти больных хронической сердечной недостаточностью
ES2750126T3 (es) 2011-03-17 2020-03-25 Critical Care Diagnostics Inc Procedimientos de predicción del riesgo de un resultado clínico adverso
US8748110B2 (en) 2011-07-18 2014-06-10 Critical Care Diagnostics, Inc. Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
MX357740B (es) 2012-05-18 2018-07-23 Critical Care Diagnostics Inc Métodos para determinar el pronóstico del tratamiento de un sujeto con un desfibrilador cardíaco implantado, un dispositivo de tratamiento de resincronización cardíaca o un dispositivo combinado de desfibrilador cardíaco implantado y de resincronización cardíaca.
MX382403B (es) 2012-08-16 2025-03-13 Critical Care Diagnostics Inc Métodos para predecir el riesgo de desarrollar hipertensión.
IN2015DN01767A (en]) 2012-08-21 2015-05-29 Critical Care Diagnostics Inc
JP6178687B2 (ja) 2013-09-27 2017-08-09 富士機械工業株式会社 グラビア塗工装置
AU2015204675A1 (en) 2014-01-10 2016-07-28 Critical Care Diagnostics, Inc. Methods and systems for determining risk of heart failure
USD770057S1 (en) 2014-04-14 2016-10-25 Critical Care Diagnostics, Inc. Blood test kit
US9934249B2 (en) 2014-06-03 2018-04-03 Conduent Business Machines Services, Llc Systems and methods for context-aware and personalized access to visualizations of road events
USD800333S1 (en) 2014-09-23 2017-10-17 Critical Care Diagnostics, Inc. Blood test kit
USD800332S1 (en) 2014-09-23 2017-10-17 Critical Care Diagnostics, Inc. Blood test kit
US10324089B2 (en) 2014-12-11 2019-06-18 Critical Care Diagnostics, Inc. Test apparatus and methods for ST2 cardiac biomarker
US10079073B2 (en) 2014-12-11 2018-09-18 Critical Care Diagnostics, Inc. Test apparatus and methods for ST2 cardiac biomarker

Also Published As

Publication number Publication date
RU2015110054A (ru) 2016-10-10
HK1208092A1 (en) 2016-02-19
US20200335220A1 (en) 2020-10-22
JP2019053086A (ja) 2019-04-04
WO2014031764A1 (en) 2014-02-27
CA2882303A1 (en) 2014-02-27
US20170169179A1 (en) 2017-06-15
EP2888687B1 (en) 2023-08-02
EP2888687A4 (en) 2016-04-13
AU2019201709B2 (en) 2021-01-07
CN111834009A (zh) 2020-10-27
JP2015532715A (ja) 2015-11-12
US10741290B2 (en) 2020-08-11
MX2020009943A (es) 2020-10-16
AU2021202116A1 (en) 2021-05-06
MX2015002254A (es) 2015-05-08
US20140058743A1 (en) 2014-02-27
JP6450679B2 (ja) 2019-01-09
SG10201608854TA (en) 2016-12-29
AU2019201709A1 (en) 2019-04-04
JP2020034573A (ja) 2020-03-05
EP2888687A1 (en) 2015-07-01
SG11201501271TA (en) 2015-03-30
MX375520B (es) 2025-03-06
JP6902083B2 (ja) 2021-07-14
CN104737170A (zh) 2015-06-24
HK1212057A1 (en) 2016-06-03
JP6621520B2 (ja) 2019-12-18
US10303844B2 (en) 2019-05-28
US20190237197A1 (en) 2019-08-01
AU2013305829A1 (en) 2015-03-05

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